Dr. Jesús Valdés Flores
Publicaciones Representativas
Investigador Titular (Cinvestav 3-C)
Doctor en Ciencias (Biología Molecular 1990) CINVESTAV.

Temas de investigación:

Metabolismo de pre-mRNAs. Splicing alternativo de transcritos marcadores de cáncer y supresores de tumores. Splicing de Entamoeba sp. Unión de proteínas y RNA: función en el splicing. Estructuras de orden superior del RNA y su relación con el splicing.
Más información...

Membresía del SNI:  Nivel I
Teléfono:  (52) (55) 5747-3954
Correo-e: jvaldes@cinvestav.mx


 

M De Nova-Ocampo, MC Soliman, W Espinosa-Hernández, C Velez-del Valle, J Salas-Benito, J Valdés-Flores, L García-Morales. Human astroviruses: in silico analysis of the untranslated region and putative binding sites of cellular proteins. Review. Molecular Biology Reports. 2018.
doi: 10.1007/s11033-018-4498-8
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FJ Rendón-Gandarilla, V Álvarez-Hernández, EJ Castañeda-Ortiz, H Cárdenas-Hernández, RE Cárdenas-Guerra, J Valdés, A Betanzos, B Chávez-Munguiía, A Lagunes-Guillen, E Orozco, L López-Canovas, E Azuara-Liceaga. Telomeric Repeat-Binding Factor Homologs in Entamoeba histolytica: New Clues for Telomeric Research. Front Cell Infect Microbiol, October 2018.
doi: 10.3389/fcimb.2018.00341
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MS Mendoza-Figueroa, EE Alfonso-Maqueira, C Vélez, EI Azuara-Liceaga, S Zárate, N Villegas-Sepúlveda, O Saucedo-Cárdenas, J Valdés. Post Splicing-Derived Full-Length Intron Circles in the Protozoan Parasite Entamoeba histolytica. Front Cell Infect Microbiol, July 2018.
doi: 10.3389/fcimb.2018.00255
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DM Torres-Cifuentes, JM Galindo-Rosales, O Saucedo-Cárdenas, J Valdés. The Entamoeba histolytica Syf1 Homolog Is Involved in the Splicing of AG-Dependent and AG-Independent Transcripts. Front Cell Infect Microbiol, 09 July 2018.
doi: 10.3389/fcimb.2018.00229
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J Valdés, C Ortuño-Pineda, O Saucedo-Cárdenas, MS Mendoza-Figueroa. Unexplored Molecular Features of the Entamoeba histolytica RNA Lariat Debranching Enzyme Dbr1 Expression Profile. Front Cell Infect Microbiol, 04 July 2018.
doi: 10.3389/fcimb.2018.00228
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J Valdés-Flores, I López-Rosas, C López-Camarillo, E Ramírez-Moreno, JD Ospina-Villa, LA Marchat. Life and Death of mRNA Molecules in Entamoeba histolytica. Front Cell Infect Microbiol, 19 June 2018.
doi: 10.3389/fcimb.2018.00199
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RK Narayanasamy, CA Castañón-Sánchez, JP Luna-Arias, G García-Rivera, B Avendaño-Borromeo, ML Labra-Barrios, J Valdés, ME Herrera-Aguirre, E Orozco. The Entamoeba histolytica TBP and TRF1 transcription factors are GAAC-box binding proteins, which display differential gene expression under different stress stimuli and during interaction with mammalian cells. Parasites and Vectors. 11 (1):153. 2018
doi: 10.1186/s13071-018-2698-7
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J Valdés, G. Kutralam-Muniasamy, B. Vergara-Porras, R. Marsch, F. Pérez-Guevara, M.R. López-Cuellar. Heterologous expression of phaC2 gene and poly-3-hydroxyalkanoate production by recombinant Cupriavidus necator strains using canola oil as carbon source. New Biotechnology. 40: 200-206. 2018.
doi: 10.1016/j.nbt.2017.08.001
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José Luis Villalpando, Rodrigo Arreola, Jonathan Puente-Rivera, Elisa Azuara-Liceaga, Jesús Valdés, Lilia López-Canovas, Alma Villalobos-Osnaya, Maria Elizbeth Alvarez-Sánchez. TvZNF1 is a C2H2 zinc finger protein of Trichomonas vaginalis. Biometals. 30, Issue 6: 86187. 2017.
doi: 10.1007/s10534-017-0053-7
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Daniela Lozano-Amado, Abril Marcela Herrera-Solorio, Jesús Valdés, Leticia Alemán-Lazarini, Ma. de Jesús Almaraz-Barrera, Eva Luna-Rivera, Miguel Vargas and Rosaura Hernández-Rivas. Identification of repressive and active epigenetic marks and nuclear bodies in Entamoeba histolytica. Parasites & Vectors 9:19. 2016.
doi: 10.1186/s13071-016-1298-7
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J. Gustavo Vázquez-Jiménez, Jesús Chávez-Reyes, Tatiana Romero-García, Ángel Zarain-Herzberg, Jesús Valdés-Flores, J. Manuel Galindo-Rosales, Angélica Rueda, Agustín Guerrero-Hernández, J. Alberto Olivares-Reyes. Palmitic acid but not palmitoleic acid induces insulin resistance in a human endothelial cell line by decreasing SERCA pump expression. Cellular Signalling. 28 (2016): 53-59;
doi: 10.1016/j.cellsig.2015.10.001
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Pedro A. Mendoza Pablo, Jesús Valdés, Luis Ortiz-Hernández. Accuracy of body mass index for age to diagnose obesity in Mexican schoolchildren. Nutr Hosp 31(6):2668-2675. 2015;
doi: 10.3305/nh.2015.31.6.8639
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Valdés, J., Nozaki, T., Sato, E., Chiba, Y., Nakada-Tsukui, K., Villegas-Sepúlveda, N., Winkler, R., Azuara-Liceaga, E., Mendoza-Figueroa, M.S., Watanabe, N., Santos, H.J., Saito-Nakano, Y., Galindo-Rosales, J.M. Proteomic analysis of Entamoeba histolytica in vivo assembled pre-mRNA splicing complexes. J Proteomics. (2014); 111: 30-45.
doi: 10.1016/j.jprot.2014.07.027
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Martínez-Salazar, M., López-Urrutia, E., Arechaga-Ocampo, E., Bonilla-Moreno, R., Martínez-Castillo, M., Díaz-Hernández, J., Del Moral-Hernández, O., Cedillo-Barrón, L., Martines-Juarez, V., De Nova-Ocampo, M., Valdés, J., Berumen, J., Villegas-Sepúlveda, N. Biochemical and proteomic analysis of spliceosome factors interacting with intron-1 of human papillomavirus type-16. J Proteomics. (2014) 111: 184-97.
doi: 10.1016/j.jprot.2014.07.029
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Wendy Espinosa-Hernández, Dora Velez-Uriza, Jesús Valdés, Cristina Vélez-Del Valle, Juan Salas-Benito, Rebeca Martínez-Contreras, Matilde García-Espítia, Mariana Salas-Benito, Tania Vega-Almeida, Mónica De Nova-Ocampo. PTB Binds to the 3' Untranslated Region of the Human Astrovirus Type 8: A Possible Role in Viral Replication. Plos One.
(2014), 9 (11): 1-10;
doi: 10.1371/journal.pone.0113113
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Ortiz-Melo, M.T., Sánchez-Guzmán, E., González-Robles, A., Valdés, J., Gómez-Flores, E., Castro-Muñozledo, F. Expression of claudins -2 and -4 and cingulin is coordinated with the start of stratification and differentiation in corneal epithelial cells: retinoic acid reversibly disrupts epithelial barrier. Biol Open. (2013) 2(2):132-143.
doi: 10.1242/bio.20123145
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Pérez Salgado, D., Valdés-Flores, J., Janssen, I., Ortiz-Hernández, L. Diagnosis and treatment of obesity among Mexican adults. Obes Facts. (2012) 5(6):937-946.
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Aguilar-Rojas, A., Huerta-Reyes, M., Maya-Núñez, G., Arechavaleta-Velásco, F., Conn, P.M., Ulloa-Aguirre, A. and Valdés, J. Gonadotropin-releasing hormone receptor activates GTPase RhoA and inhibits cell invasion in the breast cancer cell line MDA-MB-231. BMC Cancer. (2012) 12:550.
doi: 10.1186/1471-2407-12-550
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Ortuño-Pineda, C., Galindo-Rosales, J.M., Calderón-Salinas, J.V., Villegas-Sepúlveda, N., Saucedo-Cárdenas, O., De Nova-Ocampo, M., Valdés, J. Binding of hnRNP H and U2AF65 to respective G-codes and a poly-uridine tract collaborate in the N50-5'ss selection of the REST N exon in H69 cells. PLoS One. (2012) 7(7):e40315.
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López-Urrutia, E., Valdés, J., Bonilla-Moreno, R., Martínez-Salazar, M., Berumen, J. and Villegas-Sepúlveda, N. A few nucleotide polymorphisms are sufficient to recruit nuclear factosr differentially to the intron 1 of HPV-16 intratypic variants. Virus Res. (2012) 166(1-2):43-53.
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Reyes-Escogido, L., Balam-Chi, M., Rodríguez-Buenfil, I., Valdés, J., Kameyama, L., and Martínez-Pérez, F. Purification of bacterial genomic DNA in less than 20 min using chelex-100 microwave: examples from strains of lactic acid bacteria isolated from soil samples. Antonie Van Leeuwenhoek. (2010) 98(4):465-474.
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Navarro-Moreno, L.G., Quintanar-Escorza, M.A., González, S., Mondragón, R., Cerbón-Solorzáno, J.,Valdés, J. and Calderón-Salinas, J.V. Effects of lead intoxication on intercellular junctions and biochemical alterations of the renal proximal tubule cells. Toxicology in Vitro. (2009) 23(7):1298-1304.
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Ortiz-Hernández, L., Gómez-Tello, B.L. and Valdés, J. The association of sexual orientation with self-rated health, and cigarette and alcohol use in Mexican adolescents and youths. Social Science & Medicine. (2009) 69(1):85-93.
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Zavala-Flores, L.M., Villatoro-Hernandez, J., Gamez-Escobedo, A., Franco-Molina, M., Rangel-Colmenero, B.R., Villanueva-Olivo, A., Gutierrez-Puente, Y., Montes de Oca-Luna, R., Valdés, J. and Saucedo-Cardenas, O. Production of biologically active human lymphotactin (XCL1) by Lactococcus lactis. Biotechnol Lett. (2009) 31(2):215-220.
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Ortiz-Hernández, L., López-Olmedo, N.P., Genis-Gómez, M.T., Melchor-López, D.P. and Valdés-Flores, J. Application of Body Mass Index to schoolchildren of Mexico City. Ann Nutr Metab (2008) 53(3-4):205-214.
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Villatoro-Hernandez, J., Loeara-Arias, M.J., Gamez-Escobedo, A., Franco-Molina, M., Gomez-Gutierrez, J.G., Rodriguez-Rocha, H., Gutierrez-Puente, Y., Saucedo-Cardenas, O., Valdés, J. and Montes-de-Oca-Luna, R. Secretion of biologically active intereferon-gamma inducible protein-I0
(IP-I0) by Lactococcus lactis. Microbial Cell Factories. (2008) 7:22.
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Martínez, S., Fajardo, R., Valdés, J., Ulloa-Arvizu, R. and Rogelio, A. Histopathologic study of long-bone growth plates confirms the basset hound as an osteochondrodysplastic breed. Can J Vet Res. 2007; 71(1):66-69.
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Martínez-Pérez, F., Zinker, S., Aguilar, G., Valdés, J. and Aréchiga, H. Circadian oscillations of RPCH gene expression in the eyestalk of the crayfish Cherax quadricarinatus. Peptides. (2005) 26(12):2434-2444.
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Martínez-Contreras, R., Galindo, J.M., Aguilar-Rojas, A. and Valdés, J. Two exonic elements in the flanking constitutive exons control the alternative splicing of the a exon of the ZO-1 pre-mRNA. Biochim Biophys Acta. (2003) 1630(2-3):71-83.
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Martínez-Pérez, F., Becerra, A., Valdés, J., Zinker, S.and Aréchiga, H. A possible molecular ancestor for mollusk APGWamide, insect adipokinetic hormone, and crustacean red pigment concentrating hormone. J Mol Evol (2002) 54(6):703-714.
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Martínez-Pérez, F., Valdés, J., Zinker, S. and Aréchiga, H. The genomic organization of the open reading frame of the red pigment concentrating hormone gene in the blue crab Callinectes sapidus. Peptides. (2002) 23(4):781-786.
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González-Mariscal, L., Islas, S., Contreras, R.G., García-Villegas, M.R., Betanzos, A., Vega, J., Díaz-Quiñones, A., Martín-Orozco, N., Ortiz-Navarrete, V., Cereijido, M. and Valdés, J. Molecular characterization of the tight junction protein ZO-1 in MDCK cells. Exp Cell Res (1999) 248(1):97-109.
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Cereijido, M., Valdés, J., Shoshani, L. and Contreras, R.G. Role of tight junctions in stablishing and mantaining cell polarity. Annu Rev Physiol, (1998) 60:161/177.
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Valdés, J., Taylor, M.C., Cross, M.A., Ligtenberg, M.J., Rudenko, G. and Borst, P. The viral thymidine kinase gene as a tool for the study of mutagenesis in Trypanosoma brucei. Nuclei Acids Research, (1996) 24(10):1809-1815.
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Valdés, J, Hernández FC, Ocádiz R, Orozco E. Molecular karyotype of Entamoeba histolytica and Entamoeba invadens. Transactions of the Royal Society of Tropical Medicine and Hygiene, (1990) 84, 537-541.
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