Professor (Cinvestav 3-A)
Member of the National System of Investigators (SNI 1)

Investigator Scientist at
Prof. Sir John E Walker’s lab, Mitochondrial Biology Unit,
Medical Research Council, Cambridge, UK (2012-2015).

Career Development Fellow at
Dr. Andrew Carter’s lab, Laboratory of Molecular Biology,
Medical Research Council, Cambridge, UK (2015-2016).


Research lines:

Biochemical and structural analysis of the molecular motors in chronic degenerative diseases: the case of ATP synthase and dynein.
More information...


Phone:  (52) (55) 5747-3800 x 5234
E-mail: edgar.morales@cinvestav.mx


Urnavicius L, Lau CK, Elshenawy MM, Morales-Ríos E, Motz C, Yildiz A, Carter AP. Cryo-EM shows how dynactin recruits two dyneins for faster movement. Nature. (2018); Feb 7;554(7691):202-206;
doi: 10.1038/nature25462

Edgar Morales-Ríos, Martin G Montgomery, Andrew G W Leslie y John E Walker. The structure of ATP synthase from Paracoccus denitrificans determined by X-Ray crystallography at 4 Å resolution. PNAS. (2015);
Oct 27;112(43):13231-6;
doi: 10.1073/pnas.1517542112

Edgar Morales-Ríos, Ian N Watt, Qifeng Zhang, Shujing Ding, Ian M Fearnley, Martin G Montgomery, Michael JO Wakelam y John E Walker. Purification, characterisation and crystallization of the F-ATPase from Paracoccus denitrificans. Open Biology. (2015); Sep;5(9):150119;
doi: 10.1098/rsob.150119

Edgar Morales-Ríos, Martin G Montgomery, Andrew G W Leslie, José de Jesús García Trejo y John E Walker. Structure of a catalytic dimer of the α- and β- subunits of the F-ATPase from Paracoccus denitrificans at 2.3 Å resolution. Acta crystallographica. (2015); Oct;71(Pt 10):1309-17;
doi: 10.1107/S2053230X15016076

Irma Eloisa Monroy-Muñoz, Nonanzit Pérez-Hernández, José Manuel Rodríguez-Pérez, José Esteban Muñoz-Medina, Javier Ángeles-Martínez, José J. García-Trejo, Edgar Morales-Ríos, Felipe Massó, Juan Pablo Sandoval-Jones, Jorge Cervantes-Salazar, José Antonio García-Montes, Juan Calderón-Colmenero y Gilberto Vargas-Alarcón. Transcriptional Activator Domain of the Human TBX20 in Patients with Atrial Septal Defect. (2015) BioMed Research International. 2015:718786;
doi: 10.1155/2015/718786

Mariel Zarco-Zavala, Edgar Morales-Ríos, Guillermo Mendoza-Hernández, Leticia Ramírez-Silva, Gerardo Pérez-Hernández y José de de Jesús García Trejo. Novel control mechanism of the F1FO-ATP synthase nanomotor of α-proteobacteria by the inhibitory ζ subunit. The FASEB Journal. (2014); May;28(5)2146-57;
doi: 10.1096/fj.13-241430

Edgar Morales-Ríos, Fernanda de la Rosa-Morales, Guillermo Mendoza-Hernández, José S. Rodríguez-Zavala, Heliodoro Celis, Mariel Zarco-Zavala y José de Jesús García-Trejo. A novel 11-kDa inhibitory subunit in the F1FO ATP synthase of Paracoccus denitrificans and related α-proteobacteria. The FASEB Journal. (2010); Feb;24(2):599-608;
doi: 10.1096/fj.09-137356

José de Jesús García-Trejo y Edgar Morales-Ríos. Regulation of the F1FO-ATP Synthase Rotary Nanomotor in its Monomeric-Bacterial and Dimeric-Mitochondrial Forms. Journal of Biological Physics.(2008); Apr;34(1-2):197-212;
doi: 10.1007/s10867-008-9114-z

José de Jesús García-Trejo, Edgar Morales-Ríos, Paulina Cortés-Hernández y José Salud Rodríguez-Zavala. The inhibitor protein (IF1) promotes dimerization of the mitochondrial F1FO-ATP synthase. Biochemistry. (2006); Oct 24;45(42):12695-703;
doi: 10.1021/bi060339j

Concepción Bravo, Fernando Minauro-Sanmiguel, Edgar Morales-Ríos, José S. Rodríguez-Zavala y José J. García. Overexpression of the inhibitor protein IF1 in AS-30D hepatoma produces a higher association with mitochondrial F1FO ATP synthase compared to normal rat liver: functional and cross-linking studies. Journal of bioenergetics and biomembranes. (2004); Jun 36(3):257-64;
doi: 10.1023/B:JOBB.0000031977.99479.ea

CINVESTAV - Department of Biochemistry
Instituto Politécnico Nacional 2508, San Pedro Zacatenco, Zip Code 07360, México City
Phone: (52) (55) 5747-3800 x 5205